Across TCGA cell cohorts, TMPRSS11F mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible TMPRSS11F-associated genes across cancer lineages are GSG1L2, OR51T1, and OPN1MW2. Each is linked with TMPRSS11F in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11F-to-partner and partner-to-TMPRSS11F results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11F→partner) and Y-score (partner→TMPRSS11F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	2
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
STOMACH	OPN1MW2 →	+0.020	+5.285	<.001	.003	3	1
STOMACH	RLN3 →	+0.273	+5.285	<.001	.003	3	1
STOMACH	KRTAP4-2 →	+0.109	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TMPRSS11F survival (RNA) · tumor vs normal (RNA) · all TMPRSS11F data types