TMPRSS11E

Across TCGA pan-cancer cohorts, TMPRSS11E mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMPRSS11E data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMPRSS11E mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMPRSS11E expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where TMPRSS11E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.962	0.746	.002	34	view →
LUAD	DFS	Median	All	0.442	0.801	.003	32	view →
LSCC	OS	Quartile	All	0.692	0.979	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMPRSS11E–HNSC (OS)

Open the HNSC breakdown →