TMPRSS11D

Across TCGA pan-cancer cohorts, TMPRSS11D Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated TMPRSS11D data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMPRSS11D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMPRSS11D expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, SKCM, and LIHC are the cancer types where TMPRSS11D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.170	0.605	.001	36	view →
SKCM	OS	Median	All	0.218	0.788	<.001	27	view →
LIHC	OS	Median	All	0.139	0.786	<.001	24	view →
LUSC	OS	Median	All	0.081	0.818	<.001	18	view →
SARC	OS	Median	All	0.133	0.860	<.001	12	view →
KIRC	OS	Median	All	0.218	0.657	.019	10	view →
PAAD	DFS	Median	All	0.006	0.505	<.001	6	view →
STAD	DFS	Median	III,IV	0.156	0.489	.040	6	view →
PRAD	DFS	Median	All	0.125	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	III,IV	1.000	0.273	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TMPRSS11D–HNSC (DFS)

Open the HNSC breakdown →