TMPRSS11BNL

Across TCGA patient cohorts, TMPRSS11BNL mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11BNL-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and Lck. Each is linked with TMPRSS11BNL in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS11BNL-to-partner and partner-to-TMPRSS11BNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TMPRSS11BNL-low versus TMPRSS11BNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11BNL→partner) and Y-score (partner→TMPRSS11BNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.298	+3.169	.036	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.232	-3.156	.012	.020	3	1
UCEC	Lck →	-0.239	-3.169	.030	.020	3	1
UCEC	Rab25 →	-0.503	-3.169	.005	.020	3	1
UCEC	Stathmin →	+0.205	+3.169	.006	.019	3	1
UCEC	ASNS →	+0.703	+3.169	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FoxM1 by TMPRSS11BNL expression — UCEC

Explore this box plot interactively →