TMPRSS11BNL

Across TCGA pan-cancer cohorts, TMPRSS11BNL RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMPRSS11BNL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMPRSS11BNL RNA is repressed in tumor relative to normal tissue. In most cancer types TMPRSS11BNL is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.

HNSC, LUSC, and KIRP are the cancer types where TMPRSS11BNL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMPRSS11BNL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−2.090	<.001	12	view →
LUSC	All	All	+0.590	<.001	6	view →
KIRP	All	III,IV	−0.194	.044	3	view →
BRCA	All	All	+0.012	.027	2	view →
KIRC	All	All	−0.048	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMPRSS11BNL–HNSC

Open the HNSC breakdown →