TMPO

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TMPO protein abundance is significantly associated with the RNA expression of many other genes, with 17,842 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMPO-associated genes across cancer lineages are RFC5, NEK2, and KIF2C. Each is linked with TMPO in more than 8 cancer types. Because this analysis shows association rather than direction, both TMPO-to-partner and partner-to-TMPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMPO versus RFC5 in LSCC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPO→partner) and Y-score (partner→TMPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRFC5 →+1.009+0.429<.001<.00139
BRCANEK2 →+1.110+0.384<.001<.00139
UCECKIF2C →+1.270+0.345<.001<.00139
GBMDTL →+1.190+0.437<.001<.00139
UCECHMGB2 →+1.199+0.390<.001<.00139
GBMEXO1 →+1.025+0.390<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 17,842 associations by consensus.

TMPO vs RFC5 — LSCC

Per-sample scatter of TMPO vs RFC5 in LSCC (Pearson r = 0.76).

Explore this scatter interactively →

Exploration