TMPO

Across TCGA patient cohorts, TMPO mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPO-associated genes across cancer lineages are Chk2_pT68, eIF4E, and JNK_pT183_Y185. Each is linked with TMPO in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPO-to-partner and partner-to-TMPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by TMPO-low versus TMPO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPO→partner) and Y-score (partner→TMPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.149	-2.238	.007	.001	3	3
UCEC	eIF4E →	+0.204	+2.321	.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.119	-1.662	.017	.010	3	2
UCEC	Akt_pT308 →	+0.378	+1.247	.044	.041	3	2
COAD	PCNA →	+0.356	+3.008	.005	.019	3	2
COAD	PDCD4 →	-0.530	-2.991	.015	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Chk2_pT68 by TMPO expression — UCEC

Explore this box plot interactively →