TMPO

Across TCGA cell cohorts, TMPO mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMPO-associated genes across cancer lineages are OOSP2, OR10J1, and OR1L6. Each is linked with TMPO in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPO-to-partner and partner-to-TMPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP2 grouped by TMPO-low versus TMPO-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPO→partner) and Y-score (partner→TMPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OOSP2 →	+0.017	+4.781	<.001	.003	3	1
BREAST	OR10J1 →	+0.425	+4.781	<.001	.003	3	1
LUNG_SCLC	OR1L6 →	+0.038	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP9-8 →	+0.066	+5.643	<.001	.002	3	1
LUNG_SCLC	GDF2 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OOSP2 by TMPO expression — BREAST

Explore this box plot interactively →