TMPO-AS1

Across TCGA pan-cancer cohorts, TMPO-AS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TMPO-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMPO-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMPO-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where TMPO-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMPO-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.139	<.001	12	view →
KIRC	All	IV	+0.538	<.001	11	view →
BLCA	Female	III,IV	+1.320	<.001	10	view →
KIRP	All	III,IV	+0.790	<.001	10	view →
LIHC	Female	II,III,IV	+1.121	<.001	9	view →
COAD	All	II,III,IV	+0.585	<.001	9	view →
LUAD	Male	II,III,IV	+1.150	<.001	8	view →
STAD	All	II,III,IV	+0.990	<.001	8	view →
LUSC	Female	II,III,IV	+2.021	<.001	7	view →
UCEC	All	II,III,IV	+1.155	<.001	6	view →
BRCA	All	III,IV	+1.114	<.001	6	view →
THCA	All	All	−0.232	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TMPO-AS1–HNSC

Open the HNSC breakdown →