TMOD4

Across TCGA patient cohorts, TMOD4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMOD4-associated genes across cancer lineages are INPP4B, MSH2, and Paxillin. Each is linked with TMOD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMOD4-to-partner and partner-to-TMOD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TMOD4-low versus TMOD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMOD4→partner) and Y-score (partner→TMOD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.400	-3.459	.007	.005	3	1
UCEC	MSH2 →	-0.363	-3.143	<.001	.018	3	1
UCEC	Paxillin →	+0.298	+3.331	.013	.005	3	1
UCEC	P-Cadherin →	-0.159	-2.999	.018	.035	3	1
UCEC	Annexin-1 →	+0.531	+2.827	.030	.035	3	1
UCEC	TIGAR →	+0.156	+3.321	.028	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

INPP4B by TMOD4 expression — UCEC

Explore this box plot interactively →