TMOD1

Across TCGA patient cohorts, TMOD1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMOD1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, BRCA2, and Tuberin. Each is linked with TMOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMOD1-to-partner and partner-to-TMOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by TMOD1-low versus TMOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMOD1→partner) and Y-score (partner→TMOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.658	+2.817	.013	.036	3	2
UCEC	BRCA2 →	-0.133	-3.314	.046	.010	3	2
UCEC	Tuberin →	+0.376	+3.179	.007	.010	3	1
UCEC	ATM →	-0.813	-3.321	<.001	.010	3	1
UCEC	Caveolin-1 →	-0.788	-3.000	.038	.036	3	1
UCEC	Annexin-1 →	+0.971	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Acetyl-a-Tubulin-Lys40 by TMOD1 expression — UCEC

Explore this box plot interactively →