Across TCGA patient cohorts, TMLHE mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMLHE-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and mTOR_pS2448. Each is linked with TMLHE in more than 1 cancer types. Because this analysis shows association rather than direction, both TMLHE-to-partner and partner-to-TMLHE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMLHE→partner) and Y-score (partner→TMLHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.210	-1.700	.048	.044	3	1
UCEC	FoxM1 →	+0.277	+1.700	.011	.044	3	1
UCEC	mTOR_pS2448 →	-0.177	-2.906	.005	.001	3	1
UCEC	S6_pS240_S244 →	+0.360	+4.000	.036	<.001	3	1
UCEC	STAT3_pY705 →	-0.318	-2.321	.004	.033	3	1
UCEC	ATM →	-0.576	-2.906	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TMLHE survival (RNA) · tumor vs normal (RNA) · all TMLHE data types