TMF1

Across TCGA pan-cancer cohorts, TMF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMF1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TMF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

LSCC, UCEC, and HNSC are the cancer types where TMF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.578	0.937	.006	16	view →
UCEC	OS	Tertile	All	1.000	0.871	.035	10	view →
HNSC	OS	Median	All	0.957	1.000	.017	3	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
CCRCC	DFS	Quartile	III,IV	0.811	1.000	.032	2	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.769	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMF1–LSCC (OS)

Open the LSCC breakdown →