TMF1

Across TCGA pan-cancer cohorts, TMF1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TMF1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMF1 RNA is repressed in tumor relative to normal tissue. In most cancer types TMF1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and LIHC are the cancer types where TMF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.692	<.001	9	view →
LUSC	Female	II,III,IV	−1.051	<.001	7	view →
LIHC	All	All	+0.486	<.001	5	view →
CHOL	All	All	+1.216	.001	4	view →
STAD	All	II,III,IV	+0.511	.006	4	view →
KICH	All	All	−0.807	.002	3	view →
UCEC	All	All	−0.586	.005	2	view →
KIRC	Male	III,IV	−0.319	.032	2	view →
COAD	Female	All	−0.538	.030	1	view →
KIRP	Male	All	−0.349	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TMF1–THCA

Open the THCA breakdown →