TMF1

Across TCGA patient cohorts, TMF1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMF1-associated genes across cancer lineages are A-Raf_pS299, GAPDH, and PDCD4. Each is linked with TMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMF1-to-partner and partner-to-TMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TMF1-low versus TMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMF1→partner) and Y-score (partner→TMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.143	-1.906	<.001	.015	3	2
UCEC	GAPDH →	+0.428	+1.700	.017	.040	3	2
UCEC	PDCD4 →	-0.466	-1.321	.003	.029	3	2
UCEC	ATM →	-0.664	-3.074	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.688	+2.019	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.315	-3.058	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

A-Raf_pS299 by TMF1 expression — UCEC

Explore this box plot interactively →