TMEM97

Across TCGA patient cohorts, TMEM97 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM97-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ naive T-cells. Each is linked with TMEM97 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM97-to-partner and partner-to-TMEM97 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by TMEM97-low versus TMEM97-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM97→partner) and Y-score (partner→TMEM97) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.089	+6.142	<.001	.027	3	2
COAD	CD8+ Tcm →	+0.151	+5.917	<.001	.032	3	2
COAD	CD4+ naive T-cells →	+0.047	+6.142	<.001	.027	3	1
UCEC	aDC →	+0.087	+3.177	.014	.010	3	1
UCEC	CD8+ Tem →	+0.001	+4.481	.019	.047	3	1
UCEC	Macrophages →	+0.016	+1.710	.021	.047	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CD8+ T-cells by TMEM97 expression — COAD

Explore this box plot interactively →