TMEM97

Across TCGA pan-cancer cohorts, TMEM97 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TMEM97 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMEM97 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM97 expression acts as an unfavorable survival marker, although some lineages such as UCS and UVM show a favorable association.

KIRP, ACC, and SKCM are the cancer types where TMEM97 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.852	0.968	.001	117	view →
ACC	DFS	Median	All	0.257	0.658	<.001	60	view →
SKCM	OS	Tertile	All	0.244	0.394	<.001	56	view →
MESO	OS	Quartile	All	0.432	0.725	<.001	52	view →
LIHC	DFS	Quartile	III,IV	0.208	0.468	.003	52	view →
THCA	DFS	Tertile	II,III,IV	0.319	0.767	.002	40	view →
SARC	OS	Median	All	0.431	0.734	<.001	36	view →
UCS	OS	Median	IV	0.817	0.302	.002	36	view →
PAAD	DFS	Quartile	All	0.286	0.541	.002	33	view →
UVM	DFS	Quartile	All	0.834	0.460	.013	25	view →
READ	DFS	Quartile	All	0.734	0.278	.002	24	view →
HNSC	OS	Median	All	0.273	0.528	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TMEM97–KIRP (OS)

Open the KIRP breakdown →