TMEM97

Across TCGA cell cohorts, TMEM97 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,239 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM97-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, DNA replication checkpoint signaling, and DNA strand elongation. Each is linked with TMEM97 in more than 16 cancer types. Because this analysis shows association rather than direction, both TMEM97-to-partner and partner-to-TMEM97 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by TMEM97-low versus TMEM97-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM97→partner) and Y-score (partner→TMEM97) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation involved in DNA replication →	+0.185	+1.489	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.174	+1.804	<.001	<.001	3	17
BONE	DNA strand elongation →	+0.156	+1.360	<.001	<.001	3	16
KIDNEY	Mitotic DNA replication checkpoint signaling →	+0.161	+1.000	<.001	<.001	2	17
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.176	+1.945	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated DNA replication →	+0.148	+1.556	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,239 associations by consensus.

DNA strand elongation involved in DNA replication by TMEM97 expression — BONE

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