TMEM94

Across TCGA patient cohorts, TMEM94 mutation is significantly associated with the RNA expression of many other genes, with 6,280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM94-associated genes across cancer lineages are EME1, UBE2T, and EIF3I. Each is linked with TMEM94 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM94-to-partner and partner-to-TMEM94 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by TMEM94-low versus TMEM94-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM94→partner) and Y-score (partner→TMEM94) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.757	+2.858	<.001	<.001	3	4
UCEC	UBE2T →	+0.702	+2.323	<.001	<.001	3	4
UCEC	EIF3I →	+0.299	+2.992	<.001	<.001	3	4
UCEC	MND1 →	+0.813	+2.280	<.001	<.001	3	4
UCEC	ZWINT →	+0.800	+2.280	<.001	<.001	3	4
UCEC	KIF23 →	+0.701	+2.290	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,280 associations by consensus.

EME1 by TMEM94 expression — UCEC

Explore this box plot interactively →