TMEM94

Across TCGA pan-cancer cohorts, TMEM94 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TMEM94’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TMEM94 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM94 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

LIHC, KICH, and HNSC are the cancer types where TMEM94 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM94 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.422	<.001	9	view →
KICH	Female	All	−0.882	<.001	8	view →
HNSC	All	III,IV	+0.497	.004	7	view →
BLCA	All	All	+0.563	.012	6	view →
STAD	All	II,III,IV	+0.574	.007	5	view →
KIRP	Female	II,III,IV	+0.484	.009	5	view →
CHOL	Female	All	+1.930	<.001	3	view →
LUAD	All	All	−0.237	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TMEM94–LIHC

Open the LIHC breakdown →