TMEM94

Across TCGA patient cohorts, TMEM94 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM94-associated genes across cancer lineages are ASNS, PCNA, and PEA-15_pS116. Each is linked with TMEM94 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM94-to-partner and partner-to-TMEM94 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TMEM94-low versus TMEM94-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM94→partner) and Y-score (partner→TMEM94) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.366	+1.392	<.001	.017	3	4
UCEC	PCNA →	+0.235	+1.700	<.001	.001	3	3
UCEC	PEA-15_pS116 →	+0.276	+1.263	.010	.019	3	3
BLCA	JNK_pT183_Y185 →	-0.184	-2.459	.021	.020	3	2
BLCA	NF-kB-p65_pS536 →	-0.293	-2.999	.044	.035	3	2
BLCA	p38-MAPK_pT180_Y182 →	-0.410	-3.169	.025	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ASNS by TMEM94 expression — UCEC

Explore this box plot interactively →