TMEM94

Across TCGA cell cohorts, TMEM94 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,367 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM94-associated GO terms across cancer lineages are Negative regulation of transcription elongation by RNA polymerase II, Positive regulation of intracellular estrogen receptor signaling pathway, and Negative regulation of DNA-templated transcription, elongation. Each is linked with TMEM94 in more than 16 cancer types. Because this analysis shows association rather than direction, both TMEM94-to-partner and partner-to-TMEM94 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription elongation by RNA polymerase II grouped by TMEM94-low versus TMEM94-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM94→partner) and Y-score (partner→TMEM94) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of transcription elongation by RNA polymerase II →	+0.152	+1.187	<.001	.002	3	17
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.222	+1.234	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of DNA-templated transcription, elongation →	+0.154	+1.125	<.001	.004	2	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.170	+1.236	<.001	<.001	3	16
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.138	+0.854	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.136	+0.854	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,367 associations by consensus.

Negative regulation of transcription elongation by RNA polymerase II by TMEM94 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →