TMEM94

Across TCGA cell cohorts, TMEM94 mutation is significantly associated with the RNA expression of many other genes, with 781 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM94-associated genes across cancer lineages are LHCGR, MTNR1A, and TARM1. Each is linked with TMEM94 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM94-to-partner and partner-to-TMEM94 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by TMEM94-low versus TMEM94-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM94→partner) and Y-score (partner→TMEM94) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LHCGR →	+0.018	+2.034	.009	.007	3	2
LARGE_INTESTINE	MTNR1A →	+0.372	+2.386	<.001	.007	3	2
URINARY_TRACT	TARM1 →	+0.026	+5.087	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
LUNG_SCLC	C5orf52 →	+0.069	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 781 associations by consensus.

LHCGR by TMEM94 expression — LARGE_INTESTINE

Explore this box plot interactively →