TMEM92

Across TCGA patient cohorts, TMEM92 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM92-associated genes across cancer lineages are OR51I2, RNU6-517P, and HMGA1P7. Each is linked with TMEM92 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM92-to-partner and partner-to-TMEM92 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51I2 grouped by TMEM92-low versus TMEM92-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM92→partner) and Y-score (partner→TMEM92) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR51I2 →	+0.060	+5.812	<.001	.003	3	1
CESC	RNU6-517P →	+0.283	+5.201	<.001	.007	3	1
CESC	HMGA1P7 →	+0.076	+5.539	.005	.004	3	1
CESC	TRIM64EP →	+0.027	+5.969	<.001	.002	3	1
SKCM	RPS15AP7 →	+0.074	+3.809	<.001	.003	3	1
SKCM	SLC16A12-AS1 →	+0.028	+4.147	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

OR51I2 by TMEM92 expression — CESC

Explore this box plot interactively →