TMEM92

Across TCGA cell cohorts, TMEM92 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,305 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM92-associated GO terms across cancer lineages are Negative regulation of viral process, Cell-substrate junction assembly, and Apoptotic signaling pathway. Each is linked with TMEM92 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM92-to-partner and partner-to-TMEM92 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral process grouped by TMEM92-low versus TMEM92-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM92→partner) and Y-score (partner→TMEM92) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of viral process →	+0.115	+1.648	<.001	<.001	2	11
BREAST	Cell-substrate junction assembly →	+0.137	+1.219	.008	.001	3	10
LUNG_NSCLC_LUAD	Apoptotic signaling pathway →	+0.057	+1.709	<.001	<.001	3	10
PANCREAS	Regulation of tumor necrosis factor superfamily cytokine production →	+0.092	+2.048	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Hepatocyte growth factor receptor signaling pathway →	+0.256	+3.047	.001	<.001	3	10
LARGE_INTESTINE	Regulation of cytokine production involved in immune response →	+0.069	+1.794	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,305 associations by consensus.

Negative regulation of viral process by TMEM92 expression — LARGE_INTESTINE

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