TMEM92-AS1

Across TCGA pan-cancer cohorts, TMEM92-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM92-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM92-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM92-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

KIRC, BRCA, and MESO are the cancer types where TMEM92-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.499	0.747	<.001	140	view →
BRCA	DFS	Median	II,III,IV	0.855	0.919	.001	92	view →
MESO	OS	Tertile	All	0.258	0.531	<.001	73	view →
CESC	DFS	Quartile	All	0.397	0.691	<.001	64	view →
SKCM	OS	Tertile	III,IV	0.517	0.274	.002	45	view →
KIRP	DFS	Quartile	All	0.450	1.000	.001	44	view →
LGG	DFS	Median	All	0.279	0.465	<.001	44	view →
KICH	OS	Median	All	0.809	1.000	.004	31	view →
LUSC	DFS	Quartile	All	0.688	0.796	.008	23	view →
OV	OS	Median	IV	0.621	0.858	.012	22	view →
THCA	DFS	Quartile	III,IV	0.933	0.298	.001	20	view →
LIHC	OS	Median	All	0.623	0.778	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM92-AS1–KIRC (OS)

Open the KIRC breakdown →