TMEM92-AS1

Across TCGA pan-cancer cohorts, TMEM92-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM92-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM92-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM92-AS1 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where TMEM92-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM92-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.598	<.001	12	view →
KIRC	Male	All	+0.726	<.001	10	view →
THCA	Male	II,III,IV	+0.705	<.001	9	view →
KIRP	All	All	+0.700	<.001	9	view →
LUAD	Female	II,III,IV	+1.150	<.001	6	view →
COAD	Male	All	+0.534	.004	5	view →
BRCA	Female	All	+0.290	<.001	4	view →
PAAD	All	All	+1.100	.045	2	view →
STAD	Male	IV	−1.069	.013	2	view →
CHOL	Male	All	+0.733	.019	2	view →
READ	Female	All	+0.672	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM92-AS1–HNSC

Open the HNSC breakdown →