TMEM91

Across TCGA patient cohorts, TMEM91 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM91-associated genes across cancer lineages are NUTF2P8, RN7SL43P, and RNU6-492P. Each is linked with TMEM91 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM91-to-partner and partner-to-TMEM91 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTF2P8 grouped by TMEM91-low versus TMEM91-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM91→partner) and Y-score (partner→TMEM91) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUTF2P8 →	+0.195	+3.661	<.001	.001	3	1
UCEC	RN7SL43P →	+0.218	+2.812	.001	.008	3	1
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	1
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	1
BLCA	OR4C11 →	+0.069	+7.640	<.001	.009	3	1
BLCA	RNA5SP514 →	+0.278	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

NUTF2P8 by TMEM91 expression — UCEC

Explore this box plot interactively →