Across TCGA patient cohorts, TMEM89 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,058 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM89-associated proteins across cancer lineages are ORC5, DHX9, and FEN1. Each is linked with TMEM89 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM89-to-partner and partner-to-TMEM89 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM89→partner) and Y-score (partner→TMEM89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ORC5 →	+0.357	+0.666	<.001	<.001	3	5
GBM	DHX9 →	+0.238	+0.668	<.001	<.001	3	5
LSCC	FEN1 →	+0.527	+0.685	<.001	<.001	3	5
LSCC	TOP2A →	+0.796	+0.651	<.001	<.001	3	4
LSCC	TOP2A_S1106 →	+0.907	+0.648	<.001	<.001	3	4
LSCC	TOP2A_S1247 →	+0.886	+0.526	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,058 associations by consensus.

Exploration

TMEM89 survival (RNA) · tumor vs normal (RNA) · all TMEM89 data types