Across TCGA pan-cancer cohorts, TMEM88B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM88B’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM88B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM88B is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.
HNSC, LUAD, and KIRP are the cancer types where TMEM88B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM88B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.