TMEM87B

Across TCGA patient cohorts, TMEM87B mutation is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM87B-associated genes across cancer lineages are TSPY8, LINC01818, and SLC25A6P1. Each is linked with TMEM87B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM87B-to-partner and partner-to-TMEM87B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY8 grouped by TMEM87B-low versus TMEM87B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM87B→partner) and Y-score (partner→TMEM87B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TSPY8 →	+0.149	+5.739	<.001	.001	3	2
LUAD	LINC01818 →	+0.269	+6.108	<.001	.001	3	2
LUAD	SLC25A6P1 →	+0.450	+5.157	<.001	.001	3	2
LUAD	RPL7L1P1 →	+0.400	+4.628	<.001	.004	3	2
LUAD	RPL7P40 →	+0.299	+4.690	.002	.003	3	2
LUAD	CYB5AP5 →	+0.130	+4.984	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

TSPY8 by TMEM87B expression — LUAD

Explore this box plot interactively →