TMEM87B

Across TCGA pan-cancer cohorts, TMEM87B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM87B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM87B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM87B is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where TMEM87B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM87B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.422	<.001	12	view →
LUAD	Male	II,III,IV	+1.100	<.001	11	view →
STAD	Male	II,III,IV	+1.085	<.001	8	view →
BLCA	Female	III,IV	+0.820	<.001	8	view →
KIRP	All	II,III,IV	+0.672	.008	8	view →
LIHC	All	II,III,IV	+0.677	<.001	7	view →
BRCA	All	III,IV	+0.843	<.001	6	view →
CHOL	All	II,III,IV	+2.615	<.001	5	view →
COAD	Female	All	−0.594	.002	4	view →
LUSC	Male	All	+0.481	<.001	4	view →
ESCA	Female	All	+1.200	.013	2	view →
KIRC	Male	All	+0.418	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM87B–HNSC

Open the HNSC breakdown →