TMEM87B

Across TCGA cell cohorts, TMEM87B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TMEM87B-associated genes across cancer lineages are CST8, OPN1LW, and IFNA2. Each is linked with TMEM87B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM87B-to-partner and partner-to-TMEM87B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST8 grouped by TMEM87B-low versus TMEM87B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM87B→partner) and Y-score (partner→TMEM87B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CST8 →	+0.052	+4.969	<.001	.003	3	1
BREAST	OPN1LW →	+0.038	+5.169	<.001	.005	3	1
BREAST	IFNA2 →	+0.036	+5.169	<.001	.005	3	1
BREAST	IZUMO3 →	+0.035	+5.169	<.001	.005	3	1
BLOOD_Lymphoma	CT45A9 →	+0.113	+5.169	<.001	.001	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.202	+3.889	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CST8 by TMEM87B expression — BLOOD_Leukemia

Explore this box plot interactively →