TMEM86B

Across TCGA patient cohorts, TMEM86B mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM86B-associated genes across cancer lineages are LINC02559, RNU7-19P, and UBTFL7. Each is linked with TMEM86B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM86B-to-partner and partner-to-TMEM86B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by TMEM86B-low versus TMEM86B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM86B→partner) and Y-score (partner→TMEM86B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.376	+6.342	<.001	.001	3	2
SKCM	RNU7-19P →	+0.561	+5.513	<.001	.004	3	2
UCEC	UBTFL7 →	+0.127	+3.135	.003	.002	3	2
CESC	NPBWR2 →	+0.056	+5.010	<.001	.009	3	1
CESC	HMGB4 →	+0.018	+5.306	<.001	.006	3	1
CESC	RNA5SP447 →	+0.349	+5.201	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

LINC02559 by TMEM86B expression — CESC

Explore this box plot interactively →