TMEM86B

Across TCGA pan-cancer cohorts, TMEM86B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM86B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM86B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM86B is over-expressed in tumor, although a few such as PRAD and LIHC show the opposite, repressed pattern.

KIRC, KIRP, and STAD are the cancer types where TMEM86B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM86B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.530	<.001	11	view →
KIRP	All	All	+0.547	<.001	8	view →
STAD	Female	All	+1.087	<.001	5	view →
HNSC	All	All	+0.251	.007	4	view →
PRAD	All	All	−0.153	.022	2	view →
LIHC	Male	All	−0.715	.003	1	view →
READ	Female	All	+0.653	.036	1	view →
COAD	All	IV	+0.332	.034	1	view →
LUAD	All	III,IV	+0.320	.044	1	view →
LUSC	All	All	+0.230	.027	1	view →
KICH	All	All	−0.200	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM86B–KIRC

Open the KIRC breakdown →