TMEM86B

Across TCGA cell cohorts, TMEM86B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,593 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM86B-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Late viral transcription. Each is linked with TMEM86B in more than 13 cancer types. Because this analysis shows association rather than direction, both TMEM86B-to-partner and partner-to-TMEM86B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by TMEM86B-low versus TMEM86B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM86B→partner) and Y-score (partner→TMEM86B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.146	+0.772	<.001	<.001	3	14
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.191	+0.959	<.001	<.001	3	13
BONE	Late viral transcription →	+0.128	+0.938	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.157	+0.999	<.001	<.001	3	11
BONE	Microtubule nucleation →	+0.104	+0.705	<.001	<.001	3	11
BONE	Signal transduction in response to DNA damage →	+0.095	+0.890	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,593 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by TMEM86B expression — BONE

Explore this box plot interactively →