TMEM80

Across TCGA cell cohorts, TMEM80 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TMEM80-associated genes across cancer lineages are KRTAP16-1, OC90, and AGTR2. Each is linked with TMEM80 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM80-to-partner and partner-to-TMEM80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP16-1 grouped by TMEM80-low versus TMEM80-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM80→partner) and Y-score (partner→TMEM80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KRTAP16-1 →	+0.006	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	OC90 →	+0.006	+5.357	<.001	.003	3	1
BLOOD_Lymphoma	AGTR2 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR5P2 →	+0.028	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KRTAP16-1 by TMEM80 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →