TMEM80

Across TCGA pan-cancer cohorts, TMEM80 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM80 data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher TMEM80 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM80 expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

MESO, ACC, and HNSC are the cancer types where TMEM80 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.384	0.192	<.001	59	view →
ACC	DFS	Quartile	All	0.166	0.894	<.001	56	view →
HNSC	OS	Tertile	All	0.839	0.718	.001	52	view →
PAAD	OS	Tertile	All	0.527	0.277	.005	23	view →
CESC	OS	Tertile	All	0.947	0.815	.002	22	view →
BLCA	OS	Median	All	0.788	0.650	.001	21	view →
SKCM	DFS	Tertile	All	0.636	0.502	.006	19	view →
THYM	DFS	Quartile	All	0.915	0.578	<.001	18	view →
OV	DFS	Quartile	III,IV	0.153	0.253	.016	16	view →
KIRP	DFS	Median	All	0.884	0.594	.007	16	view →
READ	OS	Tertile	II,III,IV	0.816	0.558	.029	15	view →
SCLC	DFS	Tertile	II,III,IV	0.910	0.152	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM80–MESO (OS)

Open the MESO breakdown →