TMEM79

Across TCGA patient cohorts, TMEM79 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM79-associated genes across cancer lineages are MSH2, Gab2, and MEK1. Each is linked with TMEM79 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM79-to-partner and partner-to-TMEM79 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by TMEM79-low versus TMEM79-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM79→partner) and Y-score (partner→TMEM79) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.317	-2.312	.003	.034	3	2
UCEC	Gab2 →	+0.534	+2.584	.001	.011	3	1
UCEC	MEK1 →	+0.462	+2.459	.006	.018	3	1
UCEC	Notch1 →	+0.206	+2.331	.001	.019	3	1
UCEC	p21 →	+0.180	+3.000	.045	.036	3	1
UCEC	p62 Lck ligand →	+0.416	+3.331	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MSH2 by TMEM79 expression — UCEC

Explore this box plot interactively →