TMEM79

Across TCGA cell cohorts, TMEM79 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM79-associated genes across cancer lineages are SPRR2G, C16orf92, and MUC7. Each is linked with TMEM79 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM79-to-partner and partner-to-TMEM79 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR2G grouped by TMEM79-low versus TMEM79-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM79→partner) and Y-score (partner→TMEM79) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SPRR2G →	+0.069	+3.906	<.001	.009	3	1
BLOOD_Myeloma	C16orf92 →	+0.292	+3.906	.002	.009	3	1
BLOOD_Myeloma	MUC7 →	+0.023	+3.906	<.001	.009	3	1
BLOOD_Myeloma	TCP11X1 →	+0.041	+3.906	<.001	.009	3	1
LARGE_INTESTINE	ZP2 →	+0.129	+2.921	<.001	.005	3	1
LARGE_INTESTINE	KLHDC7B →	+0.636	+3.707	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

SPRR2G by TMEM79 expression — BLOOD_Myeloma

Explore this box plot interactively →