TMEM74B

Across TCGA patient cohorts, TMEM74B RNA expression is significantly associated with the go_rna of many other GO terms, with 7,161 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible TMEM74B-associated GO terms across cancer lineages are Protein localization to mitochondrion, Positive regulation of DNA repair, and Negative regulation of cell-cell adhesion mediated by cadherin. Each is linked with TMEM74B in more than 20 cancer types. Because this analysis shows association rather than direction, both TMEM74B-to-partner and partner-to-TMEM74B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to mitochondrion grouped by TMEM74B-low versus TMEM74B-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74B→partner) and Y-score (partner→TMEM74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Protein localization to mitochondrion →	+0.039	+0.951	<.001	<.001	3	21
KIRC	Positive regulation of DNA repair →	+0.034	+0.952	<.001	<.001	3	20
THYM	Negative regulation of cell-cell adhesion mediated by cadherin →	+0.084	+0.687	<.001	<.001	3	20
STAD	Mitochondrial gene expression →	+0.041	+0.583	<.001	<.001	3	20
KIRC	Protein targeting to mitochondrion →	+0.040	+0.934	<.001	<.001	3	20
THYM	Virion assembly →	+0.034	+0.438	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,161 associations by consensus.

Protein localization to mitochondrion by TMEM74B expression — KIRC

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