TMEM74B

Across TCGA patient cohorts, TMEM74B protein abundance is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM74B-associated genes across cancer lineages are PAPLN, CNTNAP3, and CRTAM. Each is linked with TMEM74B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM74B-to-partner and partner-to-TMEM74B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM74B versus PAPLN in UCEC, with a Pearson correlation of -0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74B→partner) and Y-score (partner→TMEM74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAPLN →	-1.599	-1.086	.004	<.001	3	1
UCEC	CNTNAP3 →	-1.247	-1.139	.001	<.001	3	1
UCEC	CRTAM →	-1.505	-1.037	.009	.004	3	1
UCEC	GZMK →	-1.762	-1.037	.005	.004	3	1
UCEC	SYT7 →	+2.438	+1.169	<.001	<.001	3	1
UCEC	NR3C1 →	-0.994	-1.086	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

TMEM74B vs PAPLN — UCEC

Explore this scatter interactively →