TMEM74B

Across TCGA cell cohorts, TMEM74B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM74B-associated genes across cancer lineages are GPR119, OR10W1, and ACSM6. Each is linked with TMEM74B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM74B-to-partner and partner-to-TMEM74B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by TMEM74B-low versus TMEM74B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74B→partner) and Y-score (partner→TMEM74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR119 →	+0.205	+3.115	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.015	+4.392	<.001	<.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.024	+3.584	<.001	.002	3	1
LARGE_INTESTINE	OR2D3 →	+0.022	+2.925	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GPR119 by TMEM74B expression — LARGE_INTESTINE

Explore this box plot interactively →