TMEM74B

Across TCGA cell cohorts, TMEM74B mutation is significantly associated with the mutation status of many other genes, with 2,479 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM74B-associated genes across cancer lineages are SCYL3, SIDT1, and REM1. Each is linked with TMEM74B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM74B-to-partner and partner-to-TMEM74B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCYL3 grouped by TMEM74B-low versus TMEM74B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74B→partner) and Y-score (partner→TMEM74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCYL3 →	+4.824	+5.392	.004	.004	1	2
SKIN	SIDT1 →	+4.239	+5.053	.007	.007	1	2
SKIN	REM1 →	+4.824	+5.392	.004	.004	1	2
SKIN	EEF1A2 →	+5.824	+5.824	.002	.002	1	2
SKIN	MAPK3 →	+4.824	+5.392	.004	.004	1	2
SKIN	COMP →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,479 associations by consensus.

SCYL3 by TMEM74B expression — SKIN

Explore this box plot interactively →