TMEM74

Across TCGA patient cohorts, TMEM74 protein abundance is significantly associated with the RNA expression of many other genes, with 400 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM74-associated genes across cancer lineages are ZNF207, ELMO3, and CCP110. Each is linked with TMEM74 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM74-to-partner and partner-to-TMEM74 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM74 versus ZNF207 in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74→partner) and Y-score (partner→TMEM74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF207 →	+0.556	+1.023	.001	<.001	3	1
GBM	ELMO3 →	+0.462	+1.074	.003	.007	3	1
GBM	CCP110 →	+0.788	+1.121	.006	.004	3	1
GBM	OCA2 →	+0.853	+0.967	.001	.006	3	1
GBM	TUBB4A →	+2.713	+1.181	.002	<.001	3	1
GBM	RAB3A →	+1.400	+1.074	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 400 associations by consensus.

TMEM74 vs ZNF207 — GBM

Explore this scatter interactively →