TMEM69

Across TCGA cell cohorts, TMEM69 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,409 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM69-associated GO terms across cancer lineages are Mitochondrial RNA metabolic process, 'de novo' IMP biosynthetic process, and tRNA metabolic process. Each is linked with TMEM69 in more than 15 cancer types. Because this analysis shows association rather than direction, both TMEM69-to-partner and partner-to-TMEM69 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial RNA metabolic process grouped by TMEM69-low versus TMEM69-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM69→partner) and Y-score (partner→TMEM69) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitochondrial RNA metabolic process →	+0.143	+0.798	<.001	<.001	3	16
BONE	'de novo' IMP biosynthetic process →	+0.157	+0.563	<.001	<.001	3	13
BONE	tRNA metabolic process →	+0.059	+0.479	<.001	<.001	3	12
BONE	tRNA processing →	+0.077	+0.617	<.001	.004	3	12
BONE	Mitochondrial RNA catabolic process →	+0.152	+0.653	<.001	<.001	3	12
BONE	Mitochondrial RNA processing →	+0.168	+0.702	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,409 associations by consensus.

Mitochondrial RNA metabolic process by TMEM69 expression — BONE

Explore this box plot interactively →