TMEM67

Across TCGA cell cohorts, TMEM67 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM67-associated genes across cancer lineages are LRRC52, SIGLECL1, and CST11. Each is linked with TMEM67 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM67-to-partner and partner-to-TMEM67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC52 grouped by TMEM67-low versus TMEM67-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM67→partner) and Y-score (partner→TMEM67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC52 →	+0.246	+3.684	<.001	.004	3	2
LARGE_INTESTINE	SIGLECL1 →	+0.011	+2.977	<.001	.006	3	2
BLOOD_Lymphoma	CST11 →	+1.254	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.040	+5.247	<.001	.001	3	1
LUNG_NSCLC_LUAD	PTH →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CARTPT →	+0.023	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

LRRC52 by TMEM67 expression — BLOOD_Leukemia

Explore this box plot interactively →