TMEM64

Across TCGA cell cohorts, TMEM64 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,421 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM64-associated GO terms across cancer lineages are Regulation of interleukin-6 production, DNA biosynthetic process, and Endosomal lumen acidification. Each is linked with TMEM64 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM64-to-partner and partner-to-TMEM64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of interleukin-6 production grouped by TMEM64-low versus TMEM64-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM64→partner) and Y-score (partner→TMEM64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of interleukin-6 production →	-0.091	-1.163	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.065	+1.242	.001	<.001	3	8
SKIN	Endosomal lumen acidification →	+0.131	+1.207	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of pinocytosis →	+0.083	+0.699	.002	.005	3	8
BREAST	Response to fluid shear stress →	+0.064	+1.717	<.001	.001	3	8
SOFT_TISSUE	Peptidyl-glutamate ADP-deribosylation →	-0.188	-1.145	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,421 associations by consensus.

Regulation of interleukin-6 production by TMEM64 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →