TMEM64

Across TCGA cell cohorts, TMEM64 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM64-associated genes across cancer lineages are RBMXL3, KCNA4, and HS3ST4. Each is linked with TMEM64 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM64-to-partner and partner-to-TMEM64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMXL3 grouped by TMEM64-low versus TMEM64-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM64→partner) and Y-score (partner→TMEM64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RBMXL3 →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	KCNA4 →	+0.024	+4.786	<.001	<.001	3	1
LUNG_NSCLC_LUAD	HS3ST4 →	+0.042	+4.321	<.001	.002	3	1
LUNG_NSCLC_LUAD	EXOC1L →	+0.207	+3.544	<.001	.009	3	1
LARGE_INTESTINE	C10orf53 →	+0.015	+4.047	<.001	<.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RBMXL3 by TMEM64 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →