TMEM63B

Across TCGA patient cohorts, TMEM63B RNA expression is significantly associated with the protein abundance of many other proteins, with 8,368 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM63B-associated proteins across cancer lineages are TMEM63B_S114, XPO5, and HSP90AB1. Each is linked with TMEM63B in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM63B-to-partner and partner-to-TMEM63B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM63B versus TMEM63B_S114 in LUAD, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63B→partner) and Y-score (partner→TMEM63B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TMEM63B_S114 →	+0.727	+0.679	<.001	<.001	3	5
LSCC	XPO5 →	+0.633	+0.582	<.001	<.001	3	5
LSCC	HSP90AB1 →	+0.270	+0.527	<.001	<.001	3	5
OV	ZFAND3 →	+0.626	+0.885	<.001	.002	3	4
CCRCC	TBC1D22B_S141 →	+0.559	+0.505	<.001	<.001	3	4
PDAC	KLC4 →	+0.351	+0.454	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,368 associations by consensus.

TMEM63B vs TMEM63B_S114 — LUAD

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